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Monitor Intently (1)mitotane decreases levels of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for feasible dosage changes.Doc headings differ by doc type but could comprise the following: the co